• Srp Ark Celok Lek. 2014 Sep 1; 142 (9-10): 529-34.

IntroductionUltrastructural changes in corneas of patients with diabetes mellitus have been previously described.ObjectiveThe aim of this study was to compare central corneal thickness (CDR) values in diabetic patients without retinopa- thy at the stage of diabetic nonproliferative and proliferative retinopathy and CDR in a control group of healthy subjects.MethodsThe study included 121 diabetic patients and 125 healthy subjects matched according to gender and age. Each patient underwent ophthalmological examination involving a dilated fundus examination and CDR measurement using the ultrasound pachymeter. The eyes of diabetic patients were classified according to Early Treatment Diabetic Retinopathy Study into three groups: without diabetic retinopathy (NDR), with nonproliferative diabetic retinopathy (NPDR) and a group with proliferative diabetic retinopathy (PDR). Only one eye of each subject was chosen for the study.ResultsThe mean CDR value was significantly higher in the diabetic group (570.52 ± 31.81 μm) compared with the control group (541.42 ± 27.82 μm). The difference between the two groups was statistically significant (p<0.0001). The highest mean CDR value was recorded in the PDR group (585.97 ± 28.58 μm), followed by the NPDR group (570.84 ± 30.27 μm), whereas the lowest mean CDR value was recorded in the NDR group (559.80 ± 31.55 μm). There was a statistically significant difference in CDR between the NDR and PDR groups, as well as between the NPDR and PDR groups (p < 0.001, p < 0.05 respectively). No significant difference was recorded between the NDR and NPDR groups (p>0.05).ConclusionCDR of diabetic patients was higher compared to healthy subjects. The highest mean value of CDR was registered in the PDR group, followed by the NPDR and the NDR groups.

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