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- Koutaro Murao, Yuki Mori, Yukino Takahashi, Tatsuru Ishikawa, Yuichiro Asai, Tomofumi Kobayashi, Kimiyuki Ikeda, Koji Kuronuma, Kazufumi Magara, Hiromi Fujita, Yoshihiko Hirohashi, Akira Takasawa, and Hirofumi Chiba.
- Department of Respiratory Medicine, Sapporo Kosei General Hospital, Japan.
- Intern. Med. 2022 Nov 1; 61 (21): 325932643259-3264.
AbstractPulmonary pleomorphic carcinoma is rare among lung tumors. Pulmonary pleomorphic carcinoma is resistant to chemotherapy. However, treatment with taxane anticancer agents and immune checkpoint inhibitors has been reported to be effective. When using immune checkpoint inhibitors, pseudoprogression and true progression are difficult to distinguish, and immune-related adverse events (irAEs) are common. We herein report a patient with simultaneous pseudoprogression and irAEs after combined therapy with cytotoxic agents and an immune checkpoint inhibitor for pulmonary pleomorphic carcinoma. Immune checkpoint inhibitors are effective against pulmonary pleomorphic carcinoma, but patients should be monitored for pseudoprogression and irAEs.
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