• Kosaku Komiya, Marcelo Takahiro Mitsui, Toru Watanabe, Masaru Nasu, Kazufumi Hiramatsu, and Jun-Ichi Kadota.
• Respiratory Medicine and Infectious Diseases, Oita University Faculty of Medicine, Japan.
• Intern. Med. 2022 Dec 15; 61 (24): 370937123709-3712.

AbstractA man in his 70s visited our department for dyspnea with pulmonary infiltrate that was unresolved by antibiotics. He had been taking Sansoninto for five years and doubled its dose a month ago. After discontinuing Sansoninto without any additional medications, his symptoms gradually disappeared, and pulmonary infiltration improved. Drug lymphocyte stimulation tests showed a positive result for Sansoninto. We diagnosed this patient with Sansoninto-induced lung injury. Sansoninto is a combination drug that consists of sansonin, bukuryo, senkyo, chimo, and kanzo. This paper reports the first case of Sansoninto-induced lung injury and discusses the mechanism considering its components.

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