Surgical aspects of gastrinoma in multiple endocrine neoplasia

Wien. Klin. Wochenschr. · Jan 2007

Review

Surgical aspects of gastrinoma in multiple endocrine neoplasia type 1.

Gastrinoma is the most frequent functional pancreaticoduodenal endocrine tumor in patients with multiple endocrine neoplasia type 1 (MEN1) and one major determinant of mortality in this syndrome. Whether routine surgical exploration should be performed in a patient with MEN1 associated Zollinger-Ellison syndrome (ZES) to possibly reduce the malignant spread and eventually increase survival still remains controversial. There is not only disagreement about the indication for surgical exploration, but also what type of procedure should be performed, since sufficient evidence-based data are not available. The article discusses the available data on treatment strategies of MEN1 associated ZES.

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- Detlef K Bartsch, Peter Langer, and Matthias Rothmund.
- Klinik für Allgemein- und Viszeralchirurgie der Städt. Kliniken Bielefeld-Mitte, Bielefeld, Germany. bartsch.detlef@sk-bielefeld.de
- Wien. Klin. Wochenschr. 2007 Jan 1; 119 (19-20): 602-8.
AbstractGastrinoma is the most frequent functional pancreaticoduodenal endocrine tumor in patients with multiple endocrine neoplasia type 1 (MEN1) and one major determinant of mortality in this syndrome. Whether routine surgical exploration should be performed in a patient with MEN1 associated Zollinger-Ellison syndrome (ZES) to possibly reduce the malignant spread and eventually increase survival still remains controversial. There is not only disagreement about the indication for surgical exploration, but also what type of procedure should be performed, since sufficient evidence-based data are not available. The article discusses the available data on treatment strategies of MEN1 associated ZES.

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Surgical aspects of gastrinoma in multiple endocrine neoplasia type 1.

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