• Naomi Shimada, Tomohiro Nakayama, Hiroshi Umemura, Kei Kawana, Tatsuo Yamamoto, and Seisaku Uchigasaki.
• Division of Legal Medicine, Department of Social Medicine, Nihon University School of Medicine, 30-1 Ooyaguchi-kamicho, Itabashi-ku, Tokyo 173-8610, Japan.
• Medicina (Kaunas). 2022 Apr 26; 58 (5).

AbstractHypertensive disorders of pregnancy (HDPs) are believed to comprise a group of multifactorial genetic diseases. Recently, it was reported that APELA-knockout mice exhibited HDP-like symptoms, including proteinuria and elevated blood pressure due to defective placental angiogenesis. The aim of the present study is to determine the associations between HDPs and single-nucleotide variants or haplotypes in the human APELA gene through a case-control study. The subjects were 196 pregnant women with HDPs and a control group of 254 women without HDPs. Six single-nucleotide variants (rs2068792, rs13120303, rs4541465, rs13152225, rs78639146, and rs67448487) were selected from the APELA gene region. Although there were no significant differences for each single-nucleotide polymorphism in the case-control study, the frequency of the T-A haplotypes rs4541465-rs67448487 was significantly higher in the HDP group, especially in those with gestational hypertension, than in the control group. The results suggest that the APELA gene may be a disease-susceptibility gene for HDP.

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