• Ryota Aoki and Shunsuke Nakakura.
• Department of Ophthalmology, Saneikai Tsukazaki Hospital, Himeji, Japan.
• Medicine (Baltimore). 2022 Jul 8; 101 (27): e29278e29278.

IntroductionHyphema, that is, massive anterior chamber hemorrhage, is one of the major complications after a recent minimally invasive glaucoma surgery. Hyphema along with high intraocular pressure increases the risk of corneal bloodstaining.Patient ConcernsA 71-year-old female was receiving 0.1% fluorometholone drops in both eyes for severe dry eye. She was also receiving antiplatelet agents for platelet aggregation hyperactivity and prednisolone for interstitial pneumonia internally. Her right eye was suffering from increased intraocular pressure.DiagnosisWe diagnosed her right eye as steroid-induced glaucoma.InterventionsWe performed microhook trabeculotomy.OutcomesAt postoperative day 10, she had total anterior chamber hemorrhage and high intraocular pressure, and subsequently developed corneal blood staining at postoperative day 15, for which we performed anterior chamber cleaning. After that, we did not perform additional anterior chamber cleaning, and during the 1-year follow-up, a gradual improvement was noted in the entire cornea with reddish-brown opacity, from the periphery to the center. However, almost the entire pupil was still covered with opacity, and her visual acuity was at the light perception at the final visit.LessonsCorneal bloodstaining takes a considerable time to resolve and causes severe vision loss. Special attention should be given to persistent corneal blood staining when hyphema and high intraocular pressure are observed after minimally invasive glaucoma surgeries.Copyright © 2022 the Author(s). Published by Wolters Kluwer Health, Inc.

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