• Internal medicine · Feb 2023

    Case Reports

    Pulmonary Cryptococcosis Diagnosed by a Transbronchial Lung Cryobiopsy in a Patient with Rheumatoid Arthritis.

    • Yumi Motokura, Akihiro Ito, Shinya Yokoe, Osamu Iri, Keisuke Nishimura, Shinya Kamiyama, and Tadashi Ishida.
    • Department of Respiratory Medicine, Ohara Healthcare Foundation, Kurashiki Central Hospital, Japan.
    • Intern. Med. 2023 Feb 15; 62 (4): 583587583-587.

    AbstractA 77-year-old woman with seronegative rheumatoid arthritis who was being treated with prednisolone (8 mg/day) and methotrexate (12 mg/week) visited our hospital with an 11-day history of a fever and dyspnea. Chest computed tomography showed infiltration in the right lower lobe. A transbronchial lung cryobiopsy (TBLC) showed cryptococcal cells, and bronchoalveolar lavage fluid later showed growth of Cryptococcus neoformans. She was treated with amphotericin B and flucytosine for about four weeks, and the pulmonary shadows improved. The treatment was then changed to fluconazole as outpatient consolidation and maintenance therapy. A rare case of pulmonary cryptococcosis diagnosed by a TBLC is reported.

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