• Han Wool Park, Jae Hyuk Do, Tae Young Park, Hyoung-Chul Oh, Joong-Min Park, Soon Auck Hong, and Hyun Jeong Park.
• Division of Gastroenterology, Chung-Ang University College of Medicine, Seoul, Republic of Korea.
• Medicine (Baltimore). 2022 Sep 2; 101 (35): e30371e30371.

RationaleDesmoid fibromatosis is a rare benign tumor, but due to its rarity and diverse clinical course, treatment guidelines have not been established. However, since a good prognosis can be expected, an accurate diagnosis and appropriate treatment are required. We describe a rare case of desmoid fibromatosis on young female that presented as huge abdominal mass.Patients ConcernsA 28-year-old female with left upper abdominal pain 1 month ago was referred.DiagnosesAbdominal computed tomography and magnetic resonance imaging revealed a heterogeneous soft tissue mass approximately 29 × 17 cm in size in the left abdomen with abdominal wall invasion and pathological fracture in costochondral junction of the left 8th to 10th ribs.InterventionsSurgical resection was performed.Outcomes33 × 23 × 6 cm sized tumorous mass showed proliferation of bland fibromatosis and myofibroblast with nuclear β-catenin expression on pathological examination. Desmoid fibromatosis arising from intra-abdominal soft tissue with ribs and pericardium invasion was diagnosed.LessonsThe mainstay of treatment of symptomatic desmoid fibromatosis is surgical resection, and in the case of abdominal tumor, it can be more dangerous when it invades adjacent organ. We report a case that required additionally multidisciplinary approach for surgery and postoperative treatment of huge abdominal desmoid tumor which infiltrate bone and pericardium beyond abdominal cavity.Copyright © 2022 the Author(s). Published by Wolters Kluwer Health, Inc.

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