• Arch Med Sci · Jan 2022

    A variant in microRNA-124 is involved in the control of neural cell apoptosis and associated with recovery after spinal cord injury (SCI).

    • Zhuang Zhang, Rubo Sui, and Dongjian Xia.
    • Department of Neurology, the First Affiliated Hospital, Jinzhou Medical University, Jinzhou, China.
    • Arch Med Sci. 2022 Jan 1; 18 (5): 1399-1403.

    IntroductionIn this study, we aimed to investigate the role of rs531564 and the underlying signaling pathways.MethodsFive hundred and twenty-eight spinal cord injury (SCI) patients were genotyped for the analysis of the effect of rs531564 upon the miR-124 expression.ResultsBy luciferase assays, we validated Bcl-2-like protein 11 (BIM) as a target gene of miR-124 with a negative regulatory relationship between them. We also observed that miR-124 suppressed cell viability and accelerated cell apoptosis.Conclusionsrs531564 could affect the expression of BIM by reducing the expression of miR-124, and it could be a bio-marker for the length of recovery after SCI.Copyright: © 2022 Termedia & Banach.

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