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J Neurosurg Anesthesiol · Apr 2004
Plasma ropivacaine levels following scalp block for awake craniotomy.
- Timothy Gerard Costello, John Raymond Cormack, Christopher Hoy, Andrew Wyss, Valena Braniff, Karen Martin, and Michael Murphy.
- St Vincent's Hospital, Melbourne, Australia.
- J Neurosurg Anesthesiol. 2004 Apr 1;16(2):147-50.
AbstractThe plasma levels of ropivacaine HCl with 5 mcg/mL epinephrine were measured in 10 patients following scalp blockade for awake craniotomy. A mean dose of 260 mg (3.6 mg/kg) resulted in peak plasma concentrations of 1.5 +/- 0.6 mcg/mL, with a median time to peak plasma concentration of 15 minutes. The pattern of rise of plasma level was similar in all patients and rapid compared with other regional blocks (epidural, intercostal, and axillary brachial plexus block). Despite this rapid rise of plasma level, no signs of cardiovascular or central nervous system toxicity were observed. In this group of patients undergoing awake craniotomy for excision of lesions in the eloquent areas of the cerebral cortex, ropivacaine HCl with epinephrine appeared to be a safe and effective local anesthetic agent in the dosages used.
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