• YanLi Xu, Bao-Xiang Zhang, Mao Lin, and Lu Zhang.
• School of Clinical Medicine, Weifang Medical University, Weifang, Shandong Province, P.R. China.
• Medicine (Baltimore). 2022 Oct 14; 101 (41): e31007.

RationaleThe purpose of this report was to describe resident memory cluster of differentiation 8 (CD8) + T cells may contribute to the progression of inflammatory vitiligo.Patient ConcernsA 32-year-old male has a stable vitiligo for 1 year, then some patches present inflammatory erythema. Two years later, the inflammatory patches enlarged and joined together, and the remaining 2 common patches shows repigmentation and no change respectively. Both CD69 + CD8 + T cells and CD103 + CD8 + T cells showed marked increase in inflammatory vitiligo than common vitiligo.DiagnosisHistological findings show that the numbers of lymphocytes are increased in inflammatory vitiligo than common vitiligo. Immunofluorescence staining show that the numbers of CD69 + CD8 + T cells demonstrated a marked increase in inflammatory vitiligo than common vitiligo.InterventionsWithout any intervention.OutcomesThe previous upper 2 patches on the abdomen with erythematous rim were enlarged and joined together. However the lowest lesion with uninflamed common rim on the abdomen remained static, the one on the right groin showed spot-like repigmentation.LessonsThis case report demonstrates that resident memory CD8 + T cells may contribute to the progression of inflammatory vitiligo.Copyright © 2022 the Author(s). Published by Wolters Kluwer Health, Inc.

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