• Medicina clinica · Jan 2023

    Review

    Autoimmune haemolytic anaemia.

    • María Argüello Marina, Montserrat López Rubio, and Lucía Castilla García.
    • Servicio de Hematología y Hemoterapia, Hospital Universitario Príncipe de Asturias, Alcalá de Henares, Madrid, España. Electronic address: marargumar@gmail.com.
    • Med Clin (Barc). 2023 Jan 5; 160 (1): 303830-38.

    AbstractAutoimmune haemolytic anaemias (AIHA) are acquired haematological disorders caused by increased peripheral erythrocyte destruction mediated by autoantibodies against erythrocyte antigens. They classified according to aetiology into primary and secondary, and according to the type of antibody and reaction temperature into AIHA due to warm antibodies (w-AIHA) and AIHA due to cold antibodies (c-AIHA). The mainstay of management in w-AIHA remains glucocorticoid therapy, and the early addition of rituximab has shown good results in recent studies. Primary c-AIHA is mainly treated with rituximab, alone or in combination with chemotherapy. New drugs such as Syk inhibitors, anti-FcRn Ig and complement inhibitors are in advanced development and will expand the therapeutic arsenal, especially in refractory or relapsed cases.Copyright © 2022 Elsevier España, S.L.U. All rights reserved.

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