• J S Ahluwalia, S E McNagny, and W S Clark.
• Department of Medicine, Emory University School of Medicine, Atlanta, Ga, USA.
• J Gen Intern Med. 1998 Jan 1; 13 (1): 181-8.

ObjectiveTo determine the efficacy of the transdermal nicotine patch for smoking cessation in inner-city African Americans.DesignDouble-blind, placebo-controlled, randomized trial.SettingOutpatient in an inner-city hospital.Patients And ParticipantsA computer-generated random numbers table with a block size set at 20 was used to randomize 410 patients to one of two study arms.InterventionsThe transdermal nicotine patch for 10 weeks as an adjunct to brief counseling.Measurements And Main ResultsOf the 410 patients randomized, mean age was 48 years, 65% were female, 41% had less than a high school education, 51% had an annual household income of less than $8,000, and the average number of cigarettes smoked per day was 20. Quit rates at 10 weeks were 21.5% (44/205) with the nicotine patch, and 13.7% (28/205) with the placebo patch (p = .03). At 6 months, quit rates were 17.1% (35/205) with the nicotine patch, and 11.7% (24/205) with the placebo patch (p = .08). After adjusting for baseline differences in age and educational attainment, differences remained significant at 10 weeks (p = .04), but were not significant at 6 months (p = .14). Compliance rates for return visits were 83%, 78%, 55%, and 52%, at 1, 2, 6, and 10 weeks, respectively.ConclusionsThe nicotine patch significantly improves short-term quit rates in inner-city African Americans who are interested in trying to quit smoking. Efforts should be made to reach underserved populations through smoking cessation programs, and to assist in maintaining abstinence.

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