Preconditioning and postconditioning for neuroprotection:

Best Pract Res Clin Anaesthesiol · Dec 2010

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Preconditioning and postconditioning for neuroprotection: the most recent evidence.

Stroke is a leading cause of morbidity and mortality, with perioperative stroke being an important complication in the practice of anaesthesia. Unfortunately, pharmacological treatment options are very limited and often not applicable in the perioperative period. The notion of applying a subtoxic stimulus prior to an otherwise lethal event is termed preconditioning. The main focus of the article is on describing the different concepts of preconditioning, including remote ischaemic preconditioning and anaesthetic preconditioning, as well as postconditioning and summarizing the most recent discoveries in this exciting field.

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- Stacy L Fairbanks and Ansgar M Brambrink.
- Department of Anesthesiology & Perioperative Medicine, Oregon Health & Science University, 3181 SW Sam Jackson Park Rd, UHS-2, Portland, OR 97239, USA. fairbank@ohsu.edu
- Best Pract Res Clin Anaesthesiol. 2010 Dec 1;24(4):521-34.
AbstractStroke is a leading cause of morbidity and mortality, with perioperative stroke being an important complication in the practice of anaesthesia. Unfortunately, pharmacological treatment options are very limited and often not applicable in the perioperative period. The notion of applying a subtoxic stimulus prior to an otherwise lethal event is termed preconditioning. The main focus of the article is on describing the different concepts of preconditioning, including remote ischaemic preconditioning and anaesthetic preconditioning, as well as postconditioning and summarizing the most recent discoveries in this exciting field.Copyright © 2010 Elsevier Ltd. All rights reserved.

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Preconditioning and postconditioning for neuroprotection: the most recent evidence.

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