• Presse Med · Jul 2016

    [Pathophysiology of preeclampsia].

    • Edouard Lecarpentier, Thierry Fournier, Jean Guibourdenche, and Vassilis Tsatsaris.
    • Assistance publique-Hôpitaux de Paris, centre hospitalier universitaire Cochin Broca-Hôtel-Dieu, université Paris-Descartes, 75014 Paris, France; Inserm, UMR-S 1139, 75006 Paris, France; DHU risques et grossesse, 75014 Paris, France; Fondation PremUP, 75014 Paris, France.
    • Presse Med. 2016 Jul 1; 45 (7-8 Pt 1): 631637631-7.

    AbstractPreeclampsia is a hypertensive disease of pregnancy due to abnormal utero-placental circulation. Hypoperfusion of the placenta and hypoxia/reoxygenation of the intervillous space are responsible of placental dysfunction. Trophoblastic factors are released in the maternal circulation and are responsible of the maternal endothelial dysfunction that characterize preeclampsia. Among those factors, the PlGF/sFlt-1 couple plays a major pathophysiologic role.Copyright © 2016 Elsevier Masson SAS. All rights reserved.

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