• Samer Abu-Sultaneh, Narayan Prabhu Iyer, Analía Fernández, Michael Gaies, Sebastián González-Dambrauskas, Justin Christian Hotz, KneyberMartin C JMCJ0000-0002-6008-3376Division of Paediatric Critical Care Medicine, Department of Paediatrics, Beatrix Children's Hospital, University Medical Center Groningen, University of Groningen, Groningen, the Netherlands., Yolanda M López-Fernández, Alexandre T Rotta, David K Werho, Arun Kumar Baranwal, Bronagh Blackwood, Hannah J Craven, CurleyMartha A QMAQ0000-0001-5228-6694Family and Community Health, University of Pennsylvania School of Nursing, Philadelphia, Pennsylvania.Research Institute, Children's Hospital of Philadelphia, Philadelphia, Pennsylvania., Sandrine Essouri, Jose Roberto Fioretto, Silvia M M Hartmann, Philippe Jouvet, Steven Kwasi Korang, Gerrard F Rafferty, Padmanabhan Ramnarayan, Louise Rose, Lyvonne N Tume, Elizabeth C Whipple, WongJudith J MJJM0000-0002-7987-4303KK Women's and Children's Hospital, Singapore, Singapore; and., Guillaume Emeriaud, Christopher W Mastropietro, Natalie Napolitano, NewthChristopher J LCJL0000-0002-5705-5227Keck School of Medicine, University of Southern California, Los Angeles, California.Department of Anesthesiology and Critical Care, Children's Hospital Los Angeles, Los Angeles, California., and Robinder G Khemani.
• Division of Pediatric Critical Care, Department of Pediatrics, Indiana University School of Medicine, Indianapolis, Indiana.
• Am. J. Respir. Crit. Care Med. 2023 Jan 1; 207 (1): 172817-28.

AbstractRationale: Pediatric-specific ventilator liberation guidelines are lacking despite the many studies exploring elements of extubation readiness testing. The lack of clinical practice guidelines has led to significant and unnecessary variation in methods used to assess pediatric patients' readiness for extubation. Methods: Twenty-six international experts comprised a multiprofessional panel to establish pediatrics-specific ventilator liberation clinical practice guidelines, focusing on acutely hospitalized children receiving invasive mechanical ventilation for more than 24 hours. Eleven key questions were identified and first prioritized using the Modified Convergence of Opinion on Recommendations and Evidence. A systematic review was conducted for questions that did not meet an a priori threshold of ⩾80% agreement, with Grading of Recommendations, Assessment, Development, and Evaluation methodologies applied to develop the guidelines. The panel evaluated the evidence and drafted and voted on the recommendations. Measurements and Main Results: Three questions related to systematic screening using an extubation readiness testing bundle and a spontaneous breathing trial as part of the bundle met Modified Convergence of Opinion on Recommendations criteria of ⩾80% agreement. For the remaining eight questions, five systematic reviews yielded 12 recommendations related to the methods and duration of spontaneous breathing trials, measures of respiratory muscle strength, assessment of risk of postextubation upper airway obstruction and its prevention, use of postextubation noninvasive respiratory support, and sedation. Most recommendations were conditional and based on low to very low certainty of evidence. Conclusions: This clinical practice guideline provides a conceptual framework with evidence-based recommendations for best practices related to pediatric ventilator liberation.

17 keywords...

hide…