• Jia Liu, Mingying Dai, Qiang Sun, and Wei Fang.
• College of Medicine, Qingdao University, Qingdao, China.
• Medicine (Baltimore). 2022 Dec 30; 101 (52): e32592e32592.

RationaleHypervirulent K. pneumoniae (hvKP) is a new variant of K. pneumoniae that can caused metastatic spreading by blood, including Splenic abscess, endogenous endophthalmitis, purulent meningitis. This report described a case of A typical multisite invasive infection caused by hvKP and carry out a historical review of the literature.Patient ConcernsA 55-year-old man was referred to our hospital due to liver abscess. Diabetes was found during this hospitalization. Because of glycemic was uncontrolled, splenic abscess, endogenous endophthalmitis and purulent meningitis occurred during subsequent treatment.DiagnosesWe made s diagnosis of liver abscess and invasive K. pneumoniae liver abscess syndrome through generation sequencing and imaging features.Interventions And OutcomesThe patient recovered and was subsequently discharged after mechanical ventilation, continuous renal replacement therapy, laparoscopic exploration and various antimicrobials.LessonsHvKP are very aggressive and can disseminate to multiple sites, especially in patient who have diabetes, which is a treatment challenge for clinician.Copyright © 2022 the Author(s). Published by Wolters Kluwer Health, Inc.

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