• Medicine · Jan 2023

    Review

    Mechanism of Schwann cells in diabetic peripheral neuropathy: A review.

    • Jingjing Li, Ruiqian Guan, and Limin Pan.
    • Heilongjiang University of Traditional Chinese Medicine, Harbin, Heilongjiang Province, China.
    • Medicine (Baltimore). 2023 Jan 6; 102 (1): e32653e32653.

    AbstractDiabetic peripheral neuropathy (DPN) is the most common neuropathy in the world, mainly manifested as bilateral symmetry numbness, pain or paresthesia, with a high rate of disability and mortality. Schwann cells (SCs), derived from neural ridge cells, are the largest number of glial cells in the peripheral nervous system, and play an important role in DPN. Studies have found that SCs are closely related to the pathogenesis of DPN, such as oxidative stress, endoplasmic reticulum stress, inflammation, impaired neurotrophic support and dyslipidemia. This article reviews the mechanism of SCs in DPN.Copyright © 2022 the Author(s). Published by Wolters Kluwer Health, Inc.

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