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Review
Relationship of APOE with Alzheimer's Disease and Other Neurological Disorders: An Updated Review.
- Tianwen Lou, Borui Tao, and Ming Chen.
- The First Clinical Medical College, Anhui Medical University, Hefei, China; Department of Pharmacology, School of Basic Medical Sciences, Anhui Medical University, Hefei, China.
- Neuroscience. 2023 Mar 15; 514: 123140123-140.
AbstractAlzheimer's disease (AD) and other neurodegenerative diseases, for which there is no effective cure, cause great social burden. Apolipoprotein E (APOE) is an important lipid transporter, which has been shown to have a close relationship with AD and other neurological disorders in an increasing number of studies, suggesting its potential as a therapeutic target. In this review, we summarize the recent advances in clinical and basic research on the role of APOE in the pathogenesis of multiple neurological diseases, with an emphasis on the new associations between APOE and AD, and between APOE and depression. The progress of APOE research in Parkinson's disease (PD) and some other neurological diseases is briefly discussed.Copyright © 2023 IBRO. Published by Elsevier Ltd. All rights reserved.
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