• Arif Hakan Onder, Aysegul Seremet Keskin, Kubra Demir Onder, Filiz Kizilates, and Cihan Heybeli.
• From the Department of Medical Oncology, Antalya Training and Research Hospital, Antalya, Turkiye.
• Ann Saudi Med. 2023 Jan 1; 43 (1): 191-9.

BackgroundCOVID-19 and solid cancer are both associated with an increased risk of thromboembolism.ObjectivesAssess whether solid cancer is a risk factor for acute ischemic event development among patients with COVID-19.DesignRetrospective cohort SETTING: A tertiary training and research hospital PATIENTS AND METHODS: Patients who were hospitalized for COVID-19 for ≥3 days between 15 March 2020 and 30 March 2021 at Antalya Training and Research Hospital, Antalya, Turkiye. were included in the study. Independent predictors of the development of acute ischemic events during hospitalization were determined using multivariable logistic regression analysis.Main Outcome MeasuresRisk factors for acute ischemic event development.Sample Size538 patients.ResultsPatients diagnosed with solid cancer comprised 11.3% of the cohort (n=61). Forty-one (7.6%) developed an acute ischemic event at a median of 3 (range, 1-15) days after hospitalization. The presence of a solid cancer (OR 3.80, 95% CI 1.20-12.03, P=.023) along with length of hospital stay (OR 1.05 per day, 95% CI 1.01-1.09, P=.025) were independent predictors of acute ischemic event development during the course of COVID-19. Mortality was reported in 200 (37%) patients at a median of 5 (range, 3-10) days after hospitalization. The presence of solid tumor increased mortality 5.83 times (95% CI 3.19-10.63, P<.001) while this ratio was 4.59 (95% CI 2.29-9.23, P<.001) for patients who experienced an acute ischemic event.ConclusionPatients with active cancer carry a significant risk for acute ischemic event development during the course of COVID-19 and such patients may require particular attention in terms of anticoagulation therapy.LimitationsRetrospective design and small sample size.Conflict Of InterestNone.

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