• Daniel Azoulay, Chady Salloum, Laura Llado, Emilio Ramos, Josefina Lopez-Dominguez, Alba Cachero, Joan Fabregat, Cyrille Feray, and Chetana Lim.
• Centre Hépato-Biliaire, Hôpital Universitaire Paul Brousse, Universite Paris-Saclay, Villejuif, France.
• Ann. Surg. 2023 Jan 1; 277 (1): 144150144-150.

ObjectiveTo define technically Diff-LT.Summary Of Background DataCurrently, there is no acknowledged definition of Diff-LT.MethodsThis retrospective study included all first consecutive liver-only transplantations performed in 2 centers from 2011 to 2015. Diff-LT was defined as the combination of the number of blood units transfused, cold ischemia time, and duration of operation, all at or above the median value of the entire population. The correlation of Diff-LT with short- (including the comprehensive complication index) and long-term outcomes was assessed. Outcomes were also compared to the 90-day benchmark cutoffs of LT. Predictors of Diff-LT were identified by multivariable analysis, first using only recipient data and then using all recipient, donor, graft, and surgical data.ResultsThe study population included 467 patients. The incidence of Diff- LT was 18.8%. Diff-LT was associated with short-term outcomes, including the comprehensive complication index and mortality, but not with patient or graft long-term survival. Previous abdominal surgery, intensive care unitbound at the time of LT, split graft use, nonstandard arterial reconstruction, and porto-systemic shunt ligation were independent predictors of Diff-LT. The proportion of variables below the corresponding LT 90-day benchmark cutoffs was 8/13 (61.5%) for non-Diff-LT, and 4/13 (30.8%) for Diff-LT.ConclusionsDiff-LT, as defined, occurred frequently. Adjusting modifiable variables might decrease the risk of Diff-LT and improve the postoperative course. This definition of Diff-LT might be useful for patient information, comparison between centers and surgeons, and as a metric in future trials.Copyright © 2021 Wolters Kluwer Health, Inc. All rights reserved.

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