• Mohammed Hisham Bogari, Adeeb Munshi, Saleh Almuntashiri, Asim Bogari, Abdullah Shaker Abdullah, Mohammed Albadri, Ameer Hashim, and Mohammed Saeed AlZahrani.
• From the College of Medicine, King Saud Abdulaziz University for Health Sciences, Jeddah, Saudi Arabia.
• Ann Saudi Med. 2023 Mar 1; 43 (2): 828982-89.

BackgroundAcute gastroenteritis (AGE) can cause acute kidney injury (AKI) via hypoperfusion mechanisms. Early detection of AKI caused by AGE can significantly decrease mortality rates. In Saudi Arabia, studies investigating the association between AGE and AKI are limited; thus, we aimed to fill this knowledge gap.ObjectivesAnalyze all cases of AGE reported in tertiary-care hospitals to assess the prevalence of AKI among AGE patients.DesignRetrospective cohort SETTINGS: Single tertiary-care center PATIENTS AND METHODS: The study included patients treated for AGE between October 2017 and October 2022. Stool culture was used to diagnose AGE. Inclusion criteria were infective diarrhea and/ or vomiting, and availability of data (demographics, comorbidities, malignancies, length of hospital stay, vital signs at the time of diagnosis, dehydration, causative agents of diarrhea, hemodialysis status, and laboratory data.Main Outcome MeasuresPrevalence of AKI among AGE patients and factors associated with development of AKI.Sample Size300 patients diagnosed with AGE.ResultsOf the 300 patients with AGE, 41 (13.6%) had AKI, those older than 60 years were more likely to develop AKI. The most frequent cause of AGE was Salmonella spp. (n=163, 53.3%), whereas AKI was most common in Clostridium difficile AGE patients (n=21, 51.2%). Furthermore, the most common comorbidity in the present study was malignancy, especially leukemia and lymphoma the risk of AKI was independently associated with mild dehydration, higher serum urea concentrations and low GFR values.ConclusionsPatients hospitalized for diarrheal disease are at an increased risk of developing AKI due to dehydration and comorbid conditions. It is crucial to keep kidney function in mind for AGE patients as this is associated with a high mortality rate and poor prognosis.LimitationsThe main limitation of this study was its retrospective design. Another limitation is that it is limited to a single center.Conflicts Of InterestNone.

19 keywords...

hide…