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- Honghua Yue, Yujia Zhan, Zheng Zhang, Weitao Liang, and Zhong Wu.
- Department of Cardiovascular Surgery, West China Hospital, Sichuan University, Chengdu, China.
- Arch Med Sci. 2023 Jan 1; 19 (2): 507512507-512.
IntroductionThe aim of this study was to investigate the relationship between ferroptosis and myocardial fibrosis in atrial fibrillation (AF).MethodsThe patient's left atrial appendage tissue was obtained in cardiac surgery. Sirius red staining, Prussian blue and Western blot were used to detect staining to assess histological fibrosis and ferroptosis changes.ResultsThere is a certain correlation between the degree of tissue fibrosis and ferroptosis in AF (r = 0.7763, p = 0.0004). The key proteins related to the regulation of ferroptosis were significantly abnormal in the AF group.ConclusionsFerroptosis is involved in myocardial fibrosis of AF and is a potential target for the diagnosis, prevention and treatment of AF.Copyright: © 2023 Termedia & Banach.
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