• Medicina clinica · Aug 2023

    Review

    Myasthenia gravis. Update on diagnosis and therapy.

    • Daniel Apolinar García Estévez and Julio Pardo Fernández.
    • Servicio de Neurología, Complexo Hospitalario Universitario de Ourense, Ourense, España; Grupo de investigación Neurociencias Clínicas, Instituto de Investigaciones Sanitarias Galicia-Sur, SERGAS-UVIGO, Vigo, Pontevedra, España. Electronic address: Daniel.apolinar.garcia.estevez@sergas.es.
    • Med Clin (Barc). 2023 Aug 11; 161 (3): 119127119-127.

    AbstractMyasthenia gravis is an autoimmune disease caused by the presence of specific antibodies targeting different postsynaptic components of the neuromuscular junction, and is clinically characterized by the presence of fatigueable muscle weakness. In the etiopathogenesis plays a central role the thymus and the most frequently detected pathogenic autoantibodies are targeted to the acetylcholine receptor. The increase in the knowledge of the immunological components of the neuromuscular junction in the last two decades has been fundamental to identify new pathogenic antibodies, reduce the percentage of patients with seronegative myasthenia, and propose a classification of patients into subgroups with clinical-therapeutic interest. In addition, in recent years, new drugs have been developed for the treatment of patients with myasthenia gravis that are refractory to conventional immunosuppressive treatment.Copyright © 2023 Elsevier España, S.L.U. All rights reserved.

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