• Faisal Mohammad Amin, Mohammad Sohail Asghar, Julie W Ravneberg, Patrick J H de Koning, Henrik B W Larsson, Jes Olesen, and Messoud Ashina.
• Danish Headache Center and Department of Neurology, Glostrup Hospital, Denmark.
• Cephalalgia. 2013 Sep 1;33(12):1009-16.

AimTo explore a possible differential effect of sumatriptan on extracerebral versus cerebral arteries, we examined the superficial temporal (STA), middle meningeal (MMA), extracranial internal carotid (ICAextra), intracranial internal carotid (ICAintra), middle cerebral (MCA) and basilar arteries (BA).MethodsThe arterial circumferences were recorded blindly using high-resolution magnetic resonance angiography before and after subcutaneous sumatriptan injection (6 mg) in 18 healthy volunteers.ResultsWe found significant constrictions of MMA (16.5%), STA (16.4%) and ICAextra (15.2%) ( P  ≤ 0.001). Smaller, but statistically significant, constrictions were seen in MCA (5.5%) and BA (2.1%) ( P  ≤ 0.012). ICAintra change 1.8% was not significant ( P  = 0.179). The constriction of cerebral arteries was significantly smaller than the constriction of extracerebral arteries ( P  < 0.000001).ConclusionSumatriptan constricts extracerebral arteries more than cerebral arteries. We suggest that sumatriptan may exert its anti-migraine action outside of the blood-brain barrier.

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