• Curr Pain Headache Rep · Oct 2023

    Review

    The Role of Step Therapy in the Treatment of Migraine.

    • Leon S Moskatel and Niushen Zhang.
    • Division of Headache, Department of Neurology and Neurological Sciences, Stanford University, 211 Quarry Road, Suite #206, Palo Alto, CA, 94304, USA. moskatel@stanford.edu.
    • Curr Pain Headache Rep. 2023 Oct 1; 27 (10): 571577571-577.

    Purpose Of ReviewThis review examines recent evidence and applies bioethical principles to evaluate the benefits and risks of using step therapy in the treatment of migraine.Recent FindingsWith the CGRP mAbs, gepants, and lasmiditan now on the market for up to 5 years, new research, including network meta-analyses and long-term use studies, can evaluate the comparative efficacy, tolerability, and adherence of these medications relative to older acute and preventive medications for the treatment of migraine. Deciding how medications are chosen for patients requires accounting for many factors including sustainability, efficacy, tolerability, and preference. Newer research can help give clarity on the appropriateness of gating certain treatment options behind others.© 2023. The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature.

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