• Postgraduate medicine · Sep 2023

    Association between serum vitamin C and chronic kidney disease among adults in NHANES, 2017-2018.

    • Minhua Li.
    • Department of Surgical Teaching and Research, Zhujiang Hospital, Southern Medical University, Guangzhou, Guangdong, China.
    • Postgrad Med. 2023 Sep 1; 135 (7): 701707701-707.

    ObjectiveThe current study evaluated the relationship between serum vitamin C and chronic kidney disease.MethodsThe database from the National Health and Nutrition Examination Survey (NHANES, 2017-2018) was used to perform a cross-sectional study. Multivariate logistic regression was performed to analyze the relationship between serum vitamin C and chronic kidney disease (CKD), and stratified analysis by sex was performed to assess whether there were sex differences in the association between serum vitamin C and CKD.ResultsBefore stratified analysis, multivariate logistic regression showed that serum vitamin C was negatively associated with CKD in all models (All OR > 1, P< 0.05), the risk of CKD decreased by one quantile increase in serum vitamin C (P for trend< 0.001) and low vitamin C status was associated with a higher risk of CKD (All OR > 1, P< 0.05). Stratified analyses by sex showed that the association between serum vitamin C and CKD remained negative in men, but not in women.ConclusionThere were a negative correlation between serum vitamin C and CKD, low levels of vitamin C were associated with a higher risk of CKD, and these associations were only found in men, but not in women.

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