• Ulus Travma Acil Cerrahi Derg · Sep 2023

    The comparison of the suture materials on intestinal anastomotic healing: an experimental study.

    • Osman Uzunlu, Emrah Aydin, Erdem Çomut, Esin Avcı, and Hande Şenol.
    • Department of Pediatric Surgery, Pamukkale University, School of Medicine, Denizli-Türkiye.
    • Ulus Travma Acil Cerrahi Derg. 2023 Sep 1; 29 (9): 956962956-962.

    BackgroundThis experimental comparative study was to evaluate the local effects of three different suture materials on in-testinal anastomosis healing.MethodsEthical approval was obtained from the University of Ethical Committee (E-60758568-020-176720). A prospective, experimental comparative analysis was conducted on 24 rats. They were divided into three equal groups; Group 1 underwent colonic anastomosis with Vicryl suture material, Group 2 underwent colonic anastomosis with polypropylene suture; and Group 3 underwent colonic anastomosis with polydioxanone (PDS) suture. The second operation underwent the 7th post-operative day. Adhesion score, anastomotic leakage, anastomotic bursting pressure, hydroxyproline levels, and histopathologic examination were evaluated.ResultsAll animals survived, and no leakage, intestinal obstruction, or wound infection was observed during the experiment. The adhesion score was evaluated according to the Diamond classification and same in all groups. Median anastomotic bursting pressure was 125.75 mmHg (10-241) in the Vicryl group, 159.25 mmHg (113-190) in the polypropylene group, and 154.50 mmHg (20-212) in the PDS group. Hydroxyproline tissue concentrations were in the Vicryl group 1699.92±220.8 ng/mg (range: 1509.81-2186.47), in the polypropylene group 1126.24±607.12 ng/mg (range: 53.22-1815.63), and 1547.86±335.2 ng/mg (range: 973.66-1973.2) in PDS group. There was no difference among groups regarding the inflammatory response evaluated by histopathology. There was no statistical significance in all variables evaluated.ConclusionThis experimental study demonstrates that suture materials did not worsen tissue healing during intestinal anastomosis. Absorbable, slowly-absorbable, and non-absorbable suture materials could be used safely in every situation.

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