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Pediatric emergency care · Apr 2000
Case ReportsCentral anticholinergic syndrome from orphenadrine in a 3 year old.
- M B Garza, K C Osterhoudt, and R Rutstein.
- University of Pennsylvania School of Medicine, Philadelphia, USA.
- Pediatr Emerg Care. 2000 Apr 1;16(2):97-8.
AbstractOrphenadrine (N,N-dimethyl-2(o-methyl-alpha-phenylbenzyloxy)ethylamine) is an analog of diphenhydramine with central and peripheral anticholinergic properties. It is commonly prescribed both as a muscle relaxant and as an adjunct to antipsychotic medications to prevent parkinsonism. We report a case of orphenadrine poisoning in a 3-year-old boy following ingestion of no more than two 100-mg tablets. Central anticholinergic toxicity was prominent, manifested by hallucinations and severe agitation. Orphenadrine can cause profound toxicity in children after ingestion of small doses, and should be considered as a potential cause for acute delirium in childhood.
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