• Wei Liao, Yuehui Wen, Shaochun Yang, Yanyu Duan, and Ziyou Liu.
• Department of Neurosurgery, First Affiliated of Gannan Medical University, Ganzhou, Jiangxi, China.
• Medicine (Baltimore). 2023 Oct 20; 102 (42): e35490e35490.

AbstractThere is an urgent need to find common targets for precision therapy, as there are no effective preventive therapeutic measures for combined clinical heart-brain organ protection and common pathways associated with glutamate receptors are involved in heart-brain injury, but current glutamate receptor-related clinical trials have failed. Ischemia-reperfusion injury (IRI) is a common pathological condition that occurs in multiple organs, including the heart and brain, and can lead to severe morbidity and mortality. N-methyl-D-aspartate receptor (NMDAR), a type of ionotropic glutamate receptor, plays a crucial role in the pathogenesis of IRI. NMDAR activity is mainly regulated by endogenous activators, agonists, antagonists, and voltage-gated channels, and activation leads to excessive calcium influx, oxidative stress, mitochondrial dysfunction, inflammation, apoptosis, and necrosis in ischemic cells. In this review, we summarize current research advances regarding the role of NMDAR in myocardial and cerebral IRI and discuss potential therapeutic strategies to modulate NMDAR signaling to prevent and treat IRI.Copyright © 2023 the Author(s). Published by Wolters Kluwer Health, Inc.

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