• Siming Jia, Liu Wei, Xiaoying Shi, Dacheng Sun, Tailong Shi, Hongzhi Lv, and Wei Chen.
• Trauma Emergency Center, The Third Hospital of Hebei Medical University, Shijiazhuang, Hebei, People's Republic of China.
• Medicine (Baltimore). 2023 Oct 20; 102 (42): e35575e35575.

AbstractReference intervals (RIs) of laboratory testing play a fundamental role in medical activities. RIs vary greatly for populations in different areas This study aimed to evaluate the age- and sex-specific reference intervals for a healthy population in a typical city of northern China. A cross-sectional study was performed in 4 tertiary care centers of Shijiazhuang of China, biochemical analytes were analyzed using a Beckman Coulter AU5800 (Beckman Coulter Inc., Brea, CA). A total of 42,979 healthy individuals were involved in this study. Grouped by age- and sex-specific, reference intervals of all the measures have been established. We found that different age groups of males and females have significant differences (all P < .001) in levels of various biochemical analytes. We provided a comprehensive age- and sex-specific RIs for biochemical analytes, which showed dynamic changes with both age and sex. For the local population, the reference intervals established here can be adopted in other clinical laboratories after appropriate validation.Copyright © 2023 the Author(s). Published by Wolters Kluwer Health, Inc.

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