• Shingo Hayashida, Nobuhiko Nagano, Tamaki Morohashi, Emiko Momoki, Keiko Nezu, Katsuyoshi Shimozawa, Wakako Ishii, Aya Okahashi, and Ichiro Morioka.
• Department of Pediatrics and Child Health, Nihon University School of Medicine, Tokyo, Japan.
• Medicine (Baltimore). 2023 Oct 20; 102 (42): e35565e35565.

AbstractRespiratory syncytial virus (RSV) and human metapneumovirus (hMPV) infections are common in children worldwide. However, the clinical factors related to extended hospitalization in Japanese patients aged ≥3 years remain elusive. We aimed to elucidate the clinical risk factors contributing to hospital stays ≥7 days in patients with RSV and hMPV infections. Patients ≥3 years of age who were hospitalized due to RSV or hMPV infection between 2014 to 2020 were included. Twenty-one RSV- and 27 hMPV-infected patients were enrolled. Patients were divided into 2 groups: hospitalization for ≥ and <7 days. Univariate and multivariate analyses determined the clinical risk factors contributing to hospital stay ≥7 days. The RSV- and hMPV-infected patients had similar clinical characteristics. The clinical risk factors contributing to extended hospitalization were analyzed in the 48 infected patients of the 2 groups. The presence of prophylactic antibiotics usage, co-bacterial colonization, and underlying diseases were extracted by univariate analysis (P < .05). In multivariate analysis, underlying diseases were determined as an independent clinical risk factor (odds ratio 8.09, P = .005). Underlying diseases contributed to extended hospitalization in RSV- or hMPV-infected patients ≥3 years of age.Copyright © 2023 the Author(s). Published by Wolters Kluwer Health, Inc.

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