• Youwei Yu, Yangxi Chen, Fan Yang, and Qitai Song.
• Department of Emergency Medicine, the Affiliated Hospital of Southwest Medical University, Luzhou, Sichuan Province, China.
• Medicine (Baltimore). 2023 Oct 20; 102 (42): e35609e35609.

RationaleCalciphylaxis, known as calcific uremic arteriolopathy, is a rare cause of dry gangrene. Despite an increase in the clinical recognition of demographic characteristics and risk factors associated with calciphylaxis, it remains a poorly understood disease with high mortality.Patient Concerns And DiagnosesWe present a 45-year-old man, who was diagnosed with calciphylaxis disease, with a history of diabetes mellitus, end-stage renal disease and cirrhosis with a half-month evolution of painful dry gangrene on his glans penis and scrotum. The patient also presented with gangrene of fingers.Interventions And OutcomesThe patient and his family opted for palliative care. However, he died eventually.LessonsThis case contributed to the current understanding of calciphylaxis. Since no standard treatment is available and the prognosis remained poor, early, and accurate diagnosis of calciphylaxis is important. We here report the current case and provide data for the diagnosis and treatment of this kind of disease.Copyright © 2023 the Author(s). Published by Wolters Kluwer Health, Inc.

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