• Tao Chen, Yunqian Chu, Haiyuan Xu, Hanjue Dai, Yuxi Zhou, Haiwei Du, and Wenyu Zhu.
• Department of Gastrointestinal Surgery, The Affiliated Changzhou No.2 People's Hospital with Nanjing Medical University, Changzhou, Jiangsu, China.
• Medicine (Baltimore). 2023 Oct 27; 102 (43): e35491e35491.

AbstractClinical outcomes of colon adenocarcinoma (COAD) exhibit heterogeneity among different patients, highlighting the need for novel prognostic biomarkers. Kinesin superfamily members have been shown to play a crucial role in tumors and can predict cancer diagnosis and prognosis. However, the role of kinesin family member C2 (KIFC2) in tumors, particularly its prognostic value in COAD, remains poorly understood. Our bioinformatics analysis of the cancer genome atlas and GEO databases revealed significantly higher expression of KIFC2 in COAD, correlating with a worse prognosis in the cancer genome atlas-COAD and GSE17536 cohorts. Additionally, differentially expressed genes in COAD were enriched in immune-related pathways, and patients with higher KIFC2 expression showed fewer activated CD4 + T cells. These findings suggest KIFC2 as a potential prognostic biomarker for COAD, warranting further validation in clinical studies.Copyright © 2023 the Author(s). Published by Wolters Kluwer Health, Inc.

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