• Gökalp ÖzkorkmazEbruEFaculty of Health Sciences, Ankara Yildirim Beyazit University, Ankara, Turkey., Süreyya Özdemir Başaran, Muhamet Afşin, and Firat Aşir.
• Faculty of Health Sciences, Ankara Yildirim Beyazit University, Ankara, Turkey.
• Medicine (Baltimore). 2023 Oct 27; 102 (43): e35256e35256.

BackgroundCoronavirus disease 2019 (COVID-19) is an infectious disease that has many adverse impacts on many systems including reproduction. The direct effects of COVID-19 on urogenital system are still open to argue. This study aimed to compare testosterone, follicle-stimulating hormone (FSH), luteinizing hormone (LH) and estradiol (E2) hormone levels in COVID-19 infected male individuals with infertility suspicion.MethodsOne hundred five control (healthy) and 105 COVID-19 infected males aged between 20 to 54 years old were enrolled in the study. All patients were either diagnosed with primary or secondary infertility suspicion. The COVID-19 infection was diagnosed via reverse-transcription polymerase chain reaction test. Blood samples from patients were analyzed from the control and COVID-19 group to measure serum testosterone, FSH, LH, and E2 levels. Hormone levels were statistically compared between groups with the Independent T test.ResultsIn control and COVID-19 patients, no significance was determined for FSH and LH hormone values. Testosterone hormone were significantly decreased and E2 level was statistically increased in COVID-19 patients compared to that in the control group (P < .001).ConclusionCOVID-19 is a viral disease that affects organ including gonads. COVID-19 infection decreased testosterone levels and increased E2 levels, which leading to disorders in male and female reproductivity.Copyright © 2023 the Author(s). Published by Wolters Kluwer Health, Inc.

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