• J. Korean Med. Sci. · Jun 2005

    Comparative Study

    Identification of proteins differentially expressed in the conventional renal cell carcinoma by proteomic analysis.

    • Jeong Seok Hwa, Hyo Jin Park, Jae Hun Jung, Sung Chul Kam, Hyung Chul Park, Choong Won Kim, Kee Ryeon Kang, Jea Seog Hyun, and Ky Hyun Chung.
    • Department of Urologym, College of Medicine Gyeongsang National University, Jinju, Korea. seogee@gaechuk.gsnu.ac.kr
    • J. Korean Med. Sci. 2005 Jun 1; 20 (3): 450455450-5.

    AbstractRenal cell carcinoma (RCC) is one of the most malignant tumors in urology, and due to its insidious onset patients frequently have advanced disease at the time of clinical presentation. Thus, early detection is crucial in management of RCC. To identify tumor specific proteins of RCC, we employed proteomic analysis. We prepared proteins from conventional RCC and the corresponding normal kidney tissues from seven patients with conventional RCC. The expression of proteins was determined by silver stain after two-dimensional polyacrylamide gel electrophoresis (2D-PAGE). The overall protein expression patterns in the RCC and the normal kidney tissues were quite similar except some areas. Of 66 differentially expressed protein spots (p<0.05 by Student t-test), 8 different proteins from 11 spots were identified by MALDI-TOF-MS. The expression of the following proteins was repressed (p<0.05); aminoacylase-1, enoyl-CoA hydratase, aldehyde reductase, tropomyosin alpha-4 chain, agmatinase and ketohexokinase. Two proteins, vimentin and alpha-1 antitrypsin precursor, were dominantly expressed in RCC (p<0.05).

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