• Saudi Med J · Dec 2023

    Application of arterial infusion ports in hepatic arterial infusion chemotherapy and embolization for advanced hepatocellular carcinoma.

    • Xinqiang Han, Peng Zhao, Xuemin Wang, Xiaoyu Tan, and Yongzhen Zhang.
    • From the Department of Interventional Medicine and Vascular Surgery (Han, Zhang), from the Department of Gastroenterology (Wang), and from the First Clinical Medical College (Tan), Binzhou Medical University Hospital; from the Department of Minimally Invasive (Zhao), Interventional Therapy Center, Qingdao Municipal Hospital, Shandong, China.
    • Saudi Med J. 2023 Dec 1; 44 (12): 128312891283-1289.

    ObjectivesTo investigate the safety and feasibility of subcutaneous implantable infusion ports in repeated hepatic arterial infusion chemotherapy (HAIC) for advanced hepatocellular carcinoma (HCC) in China.MethodsA total of 237 patients who were clinically diagnosed with advanced HCC (CNLC III a/III b) in our hospitals from December 2020 to October 2022 were retrospectively analyzed. The approaches of HAIC were divided into 2 groups: arterial infusion port implantation (group A) and one-time femoral artery catheterization (group B) based on the physicians' suggestion and the patients' intention. The comfort level (evaluated with the General Comfort Questionnaire), complications and average inpatient expenditure were compared between the 2 groups.Results116 patients were finally enrolled in the study (group A: 69; group B: 47) and completed HAIC (FOLFOX-4 regimen) according to the dosing schedules (mean: 6±1 cycles). The comfort level of group A was greater than that of group B (p<0.05). The average inpatient expenditure of group A was lower than that of group B (5.4±2.4 vs 10.4±1.9 thousand yuan RMB/cycle, p<0.05). No patients developed port incision infection, hematoma or catheter-related thrombosis in group A, whereas four patients had groin hematomas, one had femoral artery dissection and four had deep vein thrombosis in group B.ConclusionHepatic arterial infusion chemotherapy via arterial infusion ports for advanced HCC decreased complications and medical expenditures and improved patient comfort levels compared with indwelling catheters.Copyright: © Saudi Medical Journal.

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