• Qian Wang, Jia Hao, Wenjun Jiang, and Qiang Tan.
• From the Department of Cardiology, The first hospital of Qinhuangdao, Hebei Medical University, Qinhuangdao, Hebei, China.
• Saudi Med J. 2023 Dec 1; 44 (12): 127712821277-1282.

ObjectivesTo investigates the outcomes of enhanced external counterpulsation (EECP) among coronary microvascular disease (CMD) patients.MethodsCoronary microvascular disease patients were separated into the EECP (n=41) and control cohorts (n=42). Prior to and following the 4-week EECP program, coronary flow reserve (CFR) was recorded using transthoracic Doppler echocardiography. The serum endothelial nitric oxide synthase (eNOS) and endothelin-1 (ET-1) contents were analyzed by ELISA. Quality of life (QoL) was assessed by the Seattle Angina Questionnaire (SAQ) and the Canadian Cardiovascular Society (CCS) angina class.ResultsAfter four weeks, CFR was substantially enhanced in the EECP versus control cohort (p<0.05). Endothelin-1 was strongly diminished whereas eNOS was considerably upregulated in the EECP cohort. EECP also enhanced patients' SAQ scores and decreased the CCS angina class.ConclusionEnhanced external counterpulsation may improve CFR and enhance the CMD patient QoL.Copyright: © Saudi Medical Journal.

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