• Int J Med Sci · Jan 2024

    Review

    Novel Insights into Prokineticin 1 Role in Pregnancy-related Diseases.

    • Xi-Xi Cheng, Ming-Qing Li, and Ting Peng.
    • Shanghai Changning Maternity & Infant Health Hospital, China.
    • Int J Med Sci. 2024 Jan 1; 21 (1): 273627-36.

    AbstractProkineticin 1 (PROK1) is a secreted protein involved in a range of physiological activities such as cell proliferation, migration, angiogenesis, and neuronal cell proliferation. Emerging evidences show that PROK1/PROK receptors (PROKRs) are expressed by trophoblasts, and decidual stroma cells at the maternal-fetal interface. PROK1 plays a critical role in successful pregnancy establishment by regulating the decidualization, implantation and placental development. Dysregulation of prokineticin signaling has been described in certain pathological states associated with pregnancy, including pre-eclampsia, recurrent miscarriage and fetal growth restriction. In this review, the expression and pleiotropic roles of PROK1 under physiological and pathological pregnancy conditions are discussed.© The author(s).

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