• Postgrad Med J · May 2024

    Review

    Immunotherapy of microsatellite stable colorectal cancer: resistance mechanisms and treatment strategies.

    • Yan-Jie Han, Chi-Yun Shao, Ying Yao, Zhe Zhang, Ming-Zhi Fang, Tao Gong, Ya-Jie Zhang, and Min Li.
    • Department of Oncology, Nanjing Hospital of Chinese Medicine Affiliated to Nanjing University of Chinese Medicine, 157 Damin Road, Nanjing, Jiangsu 210001, China.
    • Postgrad Med J. 2024 May 18; 100 (1184): 373381373-381.

    AbstractIn recent years, immunotherapy strategies based on immune checkpoint inhibitors have yielded good efficacy in colorectal cancer (CRC)especially in colorectal cancer with microsatellite instability-high. However, microsatellite-stable (MSS) CRCs account for about 85% of CRCs and are resistant to immunotherapy. Previous studies have shown that compared with MSS CRC, high microsatellite instability CRC possesses a higher frequency of mutations and can generate more neoantigens. Therefore, improving the sensitivity of immunotherapy to MSS CRC is a hot topic which is crucial for the treatment of MSS CRC. This review aims to discuss the factors contributing to MSS CRC insensitivity to immunotherapy and explored potential solutions to overcome immunotherapy resistance.© The Author(s) 2024. Published by Oxford University Press on behalf of Fellowship of Postgraduate Medicine. All rights reserved. For permissions, please e-mail: journals.permissions@oup.com.

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