• Muhammad Syahrul Anwar Zainuddin and Sandrine Thuret.
• Institute of Psychiatry, Centre for the Cellular Basis of Behaviour, The James Black Centre, King's College London, London, UK.
• Br. Med. Bull. 2012 Sep 1; 103 (1): 8911489-114.

IntroductionOver the last 8 years, emerging studies bridging the gap between nutrition and mental health have resolutely established that learning and memory abilities as well as mood can be influenced by diet. However, the mechanisms by which diet modulates mental health are still not well understood. Sources of data In this article, a review of the literature was conducted using PubMed to identify studies that provide functional implications of adult hippocampal neurogenesis (AHN) and its modulation by diet.Areas Of AgreementOne of the brain structures associated with learning and memory as well as mood is the hippocampus. Importantly, the hippocampus is one of the two structures in the adult brain where the formation of newborn neurons, or neurogenesis, persists.Areas Of ControversyThe exact roles of these newborn neurons in learning, memory formation and mood regulation remain elusive.Growing PointsNevertheless, there has been accumulating evidence linking cognition and mood to neurogenesis occurring in the adult hippocampus. Therefore, modulation of AHN by diet emerges as a possible mechanism by which nutrition impacts on mental health.Areas Timely For Developing ResearchThis area of investigation is new and needs attention because a better understanding of the neurological mechanisms by which nutrition affect mental health may lead to novel dietary approaches for disease prevention, healthier ageing and discovery of new therapeutic targets for mental illnesses.

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