• Pediatric emergency care · Feb 2024

    Hyperammonemia in the Pediatric Emergency Department.

    • Christina R Rojas, Jennifer Chapman, and Debra Regier.
    • Pediatr Emerg Care. 2024 Feb 1; 40 (2): 156161156-161.

    AbstractHyperammonemia is a serious clinical condition associated with significant morbidity and mortality. In the pediatric population, this is often caused by urea cycle disorders, acute liver failure, or other less common underlying etiologies. Children and teens with hyperammonemia can have a broad range of clinical findings, including vomiting, respiratory distress, and changes in mental status. As ammonia levels worsen, this presentation can progress to respiratory failure, encephalopathy, cerebral edema, seizures, and death. Given the risk of neurologic damage, timely identification and management of hyperammonemia is critical and includes initial resuscitation, early consultation with subspecialists, and initiation of appropriate therapies. It is important for pediatric emergency medicine providers to understand the clinical findings, causes, diagnosis, and management of hyperammonemia because they play a key role in the provision of effective, multidisciplinary care of these patients.Copyright © 2024 Wolters Kluwer Health, Inc. All rights reserved.

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