• Bayan S Jan, Ahlam H Alamri, Haddad H Alkaff, Wejdan Q Almuqati, Suhail I Sayed, Sherif K Abdelmonim, Mohammad A Alessa, Osama A Marglani, Osama A Bawazir, and Ameen Z Alherabi.
• From the Department of Otorhinolaryngology Head & Neck Surgery, Al Noor Hospital, Makkah, Saudi Arabia.
• Ann Saudi Med. 2024 Jan 1; 44 (1): 394739-47.

Backgroundand Objectives: Hypocalcemia is a commonly reported complication after thyroid surgery. Many possible risk factors have been identified. The purpose of this study is to analyze various risk factors possibly associated with development of postoperative hypocalcemia after thyroid surgery by dividing the sample population into postoperative hypocalcemia and normal calcium groups.DesignRetrospective.SettingMultiple centers in the Makkah region of Saudi Arabia.Patients And MethodsRisk factors for postoperative hypocalcemia that were obtained for analysis include patient factors, perioperative blood parameters factors, disease-related factors, and surgical factors. Postoperative hypocalcemia was defined as a reduction of the total calcium level to <8.0 mg/dL. Hypocalcemic and normocalcemic patients were compared by multivariate logistic regression.Main Outcome MeasuresDistinguish independent risk factors for postoperative hypocalcemia after thyroidectomy.Sample Size215 patients.ResultsThe incidence of hypocalcemia was 52.1% (112 of 215 patients). According to multivariate analysis, statistically significant risk factors for predicting postoperative hypocalcemia included postoperative parathyroid hormone level <10 pg/dL, inadvertent parathyroid gland resection, and neck dissection surgeries.ConclusionThe causes of postoperative hypocalcemia are multi-factorial. Because many of these factors are modifiable, they should be identified postoperatively to distinguish high-risk groups and implement early preventive measures.LimitationsRetrospective with a relatively small size. We encourage additional prospective studies with a larger sample size in multiple regions of the country, which might reveal further significant results.

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