• Clinics · Jan 2024

    Relationship between semen parameters, serum InhB, and INSL-3 levels, and the degree of varicocele.

    • Lei Liu, WenJie Huang, KeBing Luo, YiZhou Zeng, YunHao Shao, and ZongMin Long.
    • Department of Urinary Surgery, The First people's hospital of Zunyi City (The third affiliated hospital of Zunyi Medical University), Zunyi, Guizhou Province, China.
    • Clinics (Sao Paulo). 2024 Jan 1; 79: 100339100339.

    BackgroundVaricocele is an abnormal expansion of the pampininias venous plexus in the scrotum, resulting in impaired sperm production and reduced sperm quality. The exact pathophysiological mechanism leading to varicocele-related infertility has not been fully elucidated. Although treatable, varicocele may lead to male infertility.ObjectiveTo investigate the relationship between semen parameters, serum InhB and INSL-3 levels, and the degree of varicocele in male patients.MethodsSerum InhB and INSL-3 were detected. To evaluate the relationship between semen parameters and serum InhB and INSL-3 levels. To evaluate the value of semen parameters and serum InhB and INSL-3 levels in distinguishing disease severity in patients with varicocele.ResultsSerum INSL-3 in patients with varicocele decreased with the severity of the disease. Serum INSL-3 was positively correlated with total sperm count and frequency of normal sperm morphology. There was a weak correlation between serum InhB and semen volume, concentration, and total sperm. Patients with different disease severity were similar within the groups, with partial overlap or similarity between varicocele Grade I and Grade II, and significant differences between Grade III and Grade I and II. Semen volume, concentration, total sperm, normal sperm morphology, and serum InhB and INSL-3 levels could distinguish the degree of varicocele.ConclusionSemen parameters and the combination of serum InhB and INSL-3 levels in patients with varicocele are closely related to the severity of the disease. Serum INSL-3 is expected to be a potential biomarker for early clinical intervention.Copyright © 2024 HCFMUSP. Published by Elsevier España, S.L.U. All rights reserved.

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