• Samara Palma Milla, Pedro P García Luna, Alfonso Vidal Casariego, Francisco Villazón González, Tomás Martín Folgueras, Olatz Izaola Jáuregui, Silvia García Rey, Alicia Calleja Fernández, Bricia López Plaza, Tamara Casañas Quintana, and Daniel A de Luis Román.
• Endocrinology and Nutrition Department, Hospital Universitario La Paz, Madrid, Spain. Electronic address: palmamillasamara@gmail.com.
• Nutrition. 2024 Apr 1; 120: 112355112355.

ObjectiveThe aim of this study was to evaluate the impact of an enhanced ONS (enriched in EPA, DHA, leucine, and beta-glucans) on the dietary intake of cancer patients.MethodsA randomized, double-blind, parallel, controlled, and multicenter clinical trial was conducted in patients with cancer and malnutrition. The trial compared prescribed dietary advice and two packs per day, for 8 weeks, of a hypercaloric (400 kcal/pack) and hyperproteic ONS (20 g/pack) with fiber and specific ingredients (leucine, EPA and DHA, and beta-glucans) (enhanced-ONS) versus an isocaloric and isoproteic formula (standard-ONS) without specific ingredients. Food intake was assessed with a 3-day dietary survey, and adherence to the supplement with a patient self-completed diary.ResultsThirty-seven patients completed the intervention period. The combined intervention of dietary advice and ONS managed to increase the energy intake of the overall cohort by 792.55 (378.57) kcal/day, protein by 40.72 (19.56) g/day. Increases in energy and nutrient intakes were observed in both groups, both in dietary intake and associated exclusively with the supplement. The group that received the enhanced-ONS ingested a greater volume of product when there was a greater severity of malnutrition; a tumor location in the head, neck, upper digestive area, liver, or pancreas; more advanced stages of the tumor; or the receipt of more than one antineoplastic treatment.ConclusionThe use of an enhanced-ONS helps meet the nutritional requirements of cancer patients, especially those who have a more compromised clinical condition, with high adherence, good tolerance, and acceptance.Copyright © 2024 The Author(s). Published by Elsevier Inc. All rights reserved.

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