• Jinxing Wan, Jun Xie, Chaohui Hu, Jiahe Liu, and Chunyan Zhu.
• Jin Xing Wan, Department of Endocrinology, Quzhou Affiliated Hospital of Wenzhou Medical University, Quzhou Peoples Hospital Zhejiang Province 100 Minjiang Avenue, Quzhou City, Zhejiang Province 324000, P.R. China.
• Pak J Med Sci. 2024 Jan 1; 40 (3Part-II): 444448444-448.

ObjectiveTo explore the clinical effect of calcium plus Vitamin-D combined with calcitriol in the treatment of patients with type-2 diabetes mellitus (T2DM) patients and osteoporosis.MethodsIn this retrospective observational study clinical records of 90 patients with T2DM combined with osteoporosis, treated in The Quzhou Affiliated Hospital of Wenzhou Medical University from October 2019 to April 2022 were incuded. All patients received basic hypoglycemic treatment. Of 90 patients, 43 received calcium plus Vitamin-D adjuvant therapy (Control-group), and 47 patients received calcium plus Vitamin-D combined with calcitriol adjuvant therapy (Observation-group). Clinical efficacy, adverse reactions, bone metabolism levels, and changes in bone density levels were compared between the two groups.ResultsThe clinical efficacy of the treatment was significantly higher in the Observation-group (93.6%) compared to the Control-group (83.7%; p<0.05). There was no statistically significant difference in the incidence of adverse reactions between the two groups (p>0.05). After treatment, bone metabolism and bone density indicators in both groups improved, and were significantly better in the Observation-group compared to the Control-group (p<0.05).ConclusionsCombination of calcium plus Vitamin-D and calcitriol adjuvant therapy in patients with T2DM and osteoporosis is safe and associated with better treatment efficacy, improved bone metabolism and bone density parameters than calcium plus Vitamin-D treatment alone.Copyright: © Pakistan Journal of Medical Sciences.

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