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J. Korean Med. Sci. · Oct 2012
Proportion of multidrug-resistant tuberculosis in human immunodeficiency virus/mycobacterium tuberculosis co-infected patients in Korea.
- Joon Sung Joh, H Christian Hong, In A Jeong, Bum Sik Chin, Hye Jin Yang, Hongjo Choi, and Ji Hwan Bang.
- Department of Internal Medicine, National Medical Center, Seoul, Korea.
- J. Korean Med. Sci. 2012 Oct 1; 27 (10): 114311461143-6.
AbstractMuch controversy surrounds the issue of whether HIV infection is a risk factor for developing multidrug-resistant tuberculosis (MDR-TB). In this study, we evaluated the prevalence of and risk factors for MDR-TB in HIV-infected patients at the National Medical Center of Korea. We reviewed the medical records of HIV/TB co-infected patients from January 2005 to May 2011; the drug susceptibility profiles were available for 55 patients. Of these, 32.7% had MDR-TB, which was approximately 3.6 times higher than the prevalence among the general population. Additionally, there were more additional AIDS-defining clinical illnesses in the MDR-TB group than in the non-MDR-TB group (27.8% vs 5.4%, P = 0.032). These results suggest that HIV infection and HIV-related immunosuppresion may contribute to the development of MDR-TB.
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