• Nicolas Sandakly, Georgio El Koubayati, Jeannette Sarkis, Samah Naderi, Delivrance Sebaaly, and Fady Haddad.
• Faculty of Medical Sciences, Lebanese University, Hadath Campus, Hadath, Lebanon.
• Medicine (Baltimore). 2024 Mar 29; 103 (13): e37626e37626.

RationaleKikuchi-Fujimoto disease (KFD) also known as histiocytic necrotizing lymphadenopathy is an exceedingly rare cause of cervical lymphadenopathy, commonly accompanied by systemic symptoms such as fever, fatigue, night sweats, myalgia, skin rash.Patient ConcernsIn this paper, we report the case of a 22-year-old female patient who experienced a flare-up of leukocytoclastic vasculitis that was complicated by the appearance of a cervical lymph node with dysphagia, fever and nausea.DiagnosisInfectious and autoimmune workup came back negative.InterventionsExcisional lymph node biopsy was done and the pathology results were consistent with histiocytic necrotizing lymphadenitis in keeping with Kikuchi-Fujimoto disease.OutcomesPatient improved on intravenous corticosteroids and was discharged on per os prednisone. Six month follow-up shows complete resolution of her symptoms.LessonsKFD should be ruled out in patients with autoimmune or inflammatory diseases who develop lymphadenopathies.Copyright © 2024 the Author(s). Published by Wolters Kluwer Health, Inc.

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