• Dongying Su, Xia Song, Fang Wu, Shufeng Fan, and Miaoer Li.
• Department of Radiology, The Second Affiliated Hospital of Zhejiang Chinese Medical University, Hangzhou, China.
• Medicine (Baltimore). 2024 Mar 29; 103 (13): e37449e37449.

RationaleClear cell carcinoma (CCC) is a highly invasive malignant tumor. CCCs of the female reproductive system occur mostly in the endometrium and ovaries and rarely in the cervix. So, it is difficult to diagnose cervical clear cell carcinoma (CCAC) on imaging. This report helps to further deepen our understanding of CCAC.Patient ConcernsA 39-year-old female patient presented with vaginal discharge with no obvious cause, elevated levels of carcinoembryonic antigen (CEA), CA125, CA153, and squamous cell carcinoma antigen (SCC), and underwent ultrasonography (US) CT and MRI examination in our hospital, which showed a mass in the cervix of the uterus, considered of cervical squamous carcinoma.DiagnosesThe cervix biopsy guided by vaginoscope biopsy and immunohistochemistry confirmed CCAC, combined Magnetic Resonance Imaging examination, CCAC with pelvic lymph node metastasis was considered.Interventions And OutcomesThe patient refused further treatment and was discharged from hospital.LessonsCCAC exhibited no specific symptoms, and is slightly different from cervical squamous carcinoma in image features, mainly relying on immunohistochemistry for diagnosis. The reported case raised awareness of CCAC.Copyright © 2024 the Author(s). Published by Wolters Kluwer Health, Inc.

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