• Jiajie Li, Jinxing Liu, Weibing Shi, and Jinchen Guo.
• School of Integrated Chinese and Western Medicine, Anhui University of Chinese Medicine, Hefei, Anhui, PR China.
• Medicine (Baltimore). 2024 Apr 19; 103 (16): e37844e37844.

AbstractDiabetes mellitus (DM) is one of the most prevalent diseases worldwide, greatly impacting patients' quality of life. This article reviews the progress in Salvia miltiorrhiza, an ancient Chinese plant, for the treatment of DM and its associated complications. Extensive studies have been conducted on the chemical composition and pharmacological effects of S miltiorrhiza, including its anti-inflammatory and antioxidant activities. It has demonstrated potential in preventing and treating diabetes and its consequences by improving peripheral nerve function and increasing retinal thickness in diabetic individuals. Moreover, S miltiorrhiza has shown effectiveness when used in conjunction with angiotensin-converting enzyme inhibitors, angiotensin receptor blockers (ARBs), and statins. The safety and tolerability of S miltiorrhiza have also been thoroughly investigated. Despite the established benefits of managing DM and its complications, further research is needed to determine appropriate usage, dosage, long-term health benefits, and safety.Copyright © 2024 the Author(s). Published by Wolters Kluwer Health, Inc.

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